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Data released on April 19, 2012

The genome of Schistosoma haematobium

Chen, F; Fang, X; Kang, Y; Li, B; Li, Y; Liu, S; Wang, J; Wang, J; Wu, X; Xiong, Z; Xu, X; Yan, Z; Yang, H; Yang, L; Zhang, G (2012): The genome of Schistosoma haematobium GigaScience. http://dx.doi.org/10.5524/100032 RIS BibTeX Text

Schistosoma haematobium is an important digenetic trematode, and is found in the Middle East, India, Portugal and Africa. It is a major agent of schistosomiasis. More specifically, it is associated with urinary schistosomiasis. Adults are found in the Venous plexuses around the urinary bladder and the released eggs traverse the wall of the bladder causing haematuria and fibrosis of the bladder. The bladder becomes calcified, and there is increased pressure on ureters and kidneys otherwise known as hydronephrosis. Inflammation of the genitals due to S.haematobium may contribute to the propagation of HIV. In this study, we sequenced the S.haematobium genome from 200 ng of genomic DNA template isolated from a single, mated pair of adult worms, and produced 33.5 Gb of usable sequence data, using Illumina-based technology at 74-fold coverage and comparedit to sequences from related parasites. We consistently showed low sequence heterozygosity and estimated the genome size to be 431-452 Mb, then assembled the data and used local assemblies to close most (96.1%) of the remaining gaps, achieving a final assembly of 385 Mb (365 contigs; N50 scaffold size 307 Kb). Also we included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.

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Related manuscripts:

doi:10.1038/ng.1065 (PubMed: 22246508)

Additional information:

http://schistodb.net/schisto/

Accessions (data not in GigaDB):

SRA: SRP011039
BioProject: PRJNA78265

Genomic

http://gigadb.org/images/data/cropped/100032_Schistosoma_haematobium.jpg

Samples: Table Settings

Columns:

Common Name
Scienfic Name
Sample Attributes
Taxonomic ID
Genbank Name

Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
SRS2972806185Flatworm Schistosoma haematobium Description:We sequenced the S. haematobium genome from 200 ng of genomic DNA template isolated from a single, mated pair (one male and one female) of adult worms, and produced 33.5 Gb of useable sequence data. We then assembled the data and used local assemblies to close most (96.1%) of the remaining gaps, achieving a final assembly of 385 Mb (365 contigs scaffold-N50 of 307 kb).
Displaying 1-1 of 1 Sample(s).

Files: (FTP site) Table Settings

Columns:

File Description
Sample ID
File Type
File Format
Size
Release Date
Download Link
File Attributes

File NameSample IDFile TypeFile FormatSizeRelease Date 
SAMPLE:SRS297280ReadmeTEXT0.36 KB2012-04-19
SAMPLE:SRS297280Sequence assemblyFASTA108.79 MB2012-04-19
SAMPLE:SRS297280Coding sequenceFASTA5.25 MB2012-04-19
SAMPLE:SRS297280AnnotationGFF850.52 KB2012-04-19
SAMPLE:SRS297280Protein sequenceFASTA3.44 MB2012-04-19
Displaying 1-5 of 5 File(s).

History:

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