Nontargeted metabolomics and lipidomics HPLC-MS data from maternal plasma of 180 healthy pregnant women.

Dataset type: Metabolomic
Data released on February 18, 2015

Luan H; Meng N; Liu P; Feng Q; Lin S; Fu J; Chen X; Weiqiao R; Chen F; Jiang H; Xu X; Cai Z; Wang J (2015): Nontargeted metabolomics and lipidomics HPLC-MS data from maternal plasma of 180 healthy pregnant women. GigaScience Database. http://dx.doi.org/10.5524/100108

DOI10.5524/100108

Metabolic variations occur during normal pregnancy to provide the growing fetus with a supply of nutrients required for its development and to ensure the health of the woman during gestation. Mass spectrometry-based metabolomics was employed to study the metabolic phenotype variations in the maternal plasma that are induced by pregnancy in each of its three trimesters.
Here we provide the LC-MS data from 180 healthy pregnant women, each individual was followed up to term to make sure that women had normal term pregnancy and healthy babies. All volunteers gave written consent and filled out individual questionnaire at the time of sample collection.
The samples were divided into six sub-groups according to the gestational week of their pregnancy at the time of sampling, T1 (n= 30, 9-12 weeks), T2 (n=30, 13-16 weeks), T3 (n=30, 17-20 weeks), T4 (n=30, 21-24 weeks), T5 (n=30, 25-28 weeks), and T6 (n=30, 29-40 weeks). Body mass index (BMI), age, and gestational week were recorded for each individual.
The repository contains data in 3 modalities: positive and negative ion 'global' non-targeted LC-MS and shotgun lipidomics (including carnitine profiling) LC-MS.

Additional details

Read the peer-reviewed publication(s):

Luan, H., Meng, N., Liu, P., Feng, Q., Lin, S., Fu, J., … Wang, J. (2014). Pregnancy-Induced Metabolic Phenotype Variations in Maternal Plasma. Journal of Proteome Research, 13(3), 1527–1536. doi:10.1021/pr401068k
Luan, H., Meng, N., Liu, P., Fu, J., Chen, X., Rao, W., … Wang, J. (2015). Non-targeted metabolomics and lipidomics LC–MS data from maternal plasma of 180 healthy pregnant women. GigaScience, 4(1). doi:10.1186/s13742-015-0054-9

Related datasets:

doi:10.5524/100108 IsReferencedBy doi:10.5524/100146

Accessions (data included in GigaDB):

MetaboLights: MTBLS146





Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
PDP12AE00291-49606HumanhumanHomo sapiens Age:25
Alternative names:F01
Body product:blood plasma
...
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PDP12AI00290-49606HumanhumanHomo sapiens Age:26
Alternative names:A01
Body product:blood plasma
...
+
PDP12AI00296-49606HumanhumanHomo sapiens Age:37
Alternative names:F02
Body product:blood plasma
...
+
PDP12AI00317-49606HumanhumanHomo sapiens Age:33
Alternative names:A02
Body product:blood plasma
...
+
PDP12AJ02668-49606HumanhumanHomo sapiens Age:21
Alternative names:F03
Body product:blood plasma
...
+
PDP12AJ02799-49606HumanhumanHomo sapiens Age:21
Alternative names:F04
Body product:blood plasma
...
+
PDP12AJ02948-49606HumanhumanHomo sapiens Age:36
Alternative names:F05
Body product:blood plasma
...
+
PDP12AJ02988-49606HumanhumanHomo sapiens Age:23
Alternative names:F06
Body product:blood plasma
...
+
PDP12AJ03026-49606HumanhumanHomo sapiens Age:32
Alternative names:F07
Body product:blood plasma
...
+
PDP12AJ03070-49606HumanhumanHomo sapiens Age:22
Alternative names:A03
Body product:blood plasma
...
+
Displaying 1-10 of 181 Sample(s).




File NameSample IDData TypeFile FormatSizeRelease Date 
PDP12AR02507-4Mass Spectrometry datamzML29.96 MB2015-02-18
PDP12AR02707-4Mass Spectrometry datamzML30.28 MB2015-02-18
PDP12AR02720-4Mass Spectrometry datamzML30.31 MB2015-02-18
PDP12AR02812-4Mass Spectrometry datamzML30.08 MB2015-02-18
PDP12AE00291-4Mass Spectrometry datamzML30.32 MB2015-02-18
PDP12HG00001-4Mass Spectrometry datamzML33.01 MB2015-02-18
PDP12AI00290-4Mass Spectrometry datamzML30.43 MB2015-02-18
PDP12AI00296-4Mass Spectrometry datamzML32 MB2015-02-18
PDP12AI00317-4Mass Spectrometry datamzML30.28 MB2015-02-18
PDP12AJ02668-4Mass Spectrometry datamzML30.55 MB2015-02-18
Displaying 1-10 of 635 File(s).
Date Action
October 19, 2015 File global_negative_AB02507_2.mzML updated
October 19, 2015 File global_negative_AB02720_2.mzML updated
June 3, 2016 Link added : MetaboLights:MTBLS146