Data released on February 18, 2015
Metabolic variations occur during normal pregnancy to provide the growing fetus with a supply of nutrients required for its development and to ensure the health of the woman during gestation. Mass spectrometry-based metabolomics was employed to study the metabolic phenotype variations in the maternal plasma that are induced by pregnancy in each of its three trimesters.
Here we provide the LC-MS data from 180 healthy pregnant women, each individual was followed up to term to make sure that women had normal term pregnancy and healthy babies. All volunteers gave written consent and filled out individual questionnaire at the time of sample collection.
The samples were divided into six sub-groups according to the gestational week of their pregnancy at the time of sampling, T1 (n= 30, 9-12 weeks), T2 (n=30, 13-16 weeks), T3 (n=30, 17-20 weeks), T4 (n=30, 21-24 weeks), T5 (n=30, 25-28 weeks), and T6 (n=30, 29-40 weeks). Body mass index (BMI), age, and gestational week were recorded for each individual.
The repository contains data in 3 modalities: positive and negative ion 'global' non-targeted LC-MS and shotgun lipidomics (including carnitine profiling) LC-MS.
Luan, H., Meng, N., Liu, P., Feng, Q., Lin, S., Fu, J., … Wang, J. (2014). Pregnancy-Induced Metabolic Phenotype Variations in Maternal Plasma. Journal of Proteome Research, 13(3), 1527–1536. doi:10.1021/pr401068k
Luan, H., Meng, N., Liu, P., Fu, J., Chen, X., Rao, W., … Wang, J. (2015). Non-targeted metabolomics and lipidomics LC–MS data from maternal plasma of 180 healthy pregnant women. GigaScience, 4(1). doi:10.1186/s13742-015-0054-9