Nontargeted metabolomics and lipidomics HPLC-MS data from maternal plasma of 180 healthy pregnant women.
Dataset type: Metabolomic
Data released on February 18, 2015
Metabolic variations occur during normal pregnancy to provide the growing fetus with a supply of nutrients required for its development and to ensure the health of the woman during gestation. Mass spectrometry-based metabolomics was employed to study the metabolic phenotype variations in the maternal plasma that are induced by pregnancy in each of its three trimesters.
Here we provide the LC-MS data from 180 healthy pregnant women, each individual was followed up to term to make sure that women had normal term pregnancy and healthy babies. All volunteers gave written consent and filled out individual questionnaire at the time of sample collection.
The samples were divided into six sub-groups according to the gestational week of their pregnancy at the time of sampling, T1 (n= 30, 9-12 weeks), T2 (n=30, 13-16 weeks), T3 (n=30, 17-20 weeks), T4 (n=30, 21-24 weeks), T5 (n=30, 25-28 weeks), and T6 (n=30, 29-40 weeks). Body mass index (BMI), age, and gestational week were recorded for each individual.
The repository contains data in 3 modalities: positive and negative ion 'global' non-targeted LC-MS and shotgun lipidomics (including carnitine profiling) LC-MS.
Additional details
Read the peer-reviewed publication(s):
(PubMed: 24450375)
(PubMed: 25859341)
Related datasets:
doi:10.5524/100108 IsReferencedBy doi:10.5524/100146
Accessions (data generated as part of this study):
MetaboLights:
MTBLS146
Sample ID | Taxonomic ID | Common Name | Genbank Name | Scientific Name | Sample Attributes |
---|---|---|---|---|---|
PDP12AE00291-4 | 9606 | Human | human | Homo sapiens | Age:25 Alternative names:F01 Body product:blood plasma [UBERON:0001969] ... + |
PDP12AI00290-4 | 9606 | Human | human | Homo sapiens | Age:26 Alternative names:A01 Body product:blood plasma [UBERON:0001969] ... + |
PDP12AI00296-4 | 9606 | Human | human | Homo sapiens | Age:37 Alternative names:F02 Body product:blood plasma [UBERON:0001969] ... + |
PDP12AI00317-4 | 9606 | Human | human | Homo sapiens | Age:33 Alternative names:A02 Body product:blood plasma [UBERON:0001969] ... + |
PDP12AJ02668-4 | 9606 | Human | human | Homo sapiens | Age:21 Alternative names:F03 Body product:blood plasma [UBERON:0001969] ... + |
PDP12AJ02799-4 | 9606 | Human | human | Homo sapiens | Age:21 Alternative names:F04 Body product:blood plasma [UBERON:0001969] ... + |
PDP12AJ02948-4 | 9606 | Human | human | Homo sapiens | Age:36 Alternative names:F05 Body product:blood plasma [UBERON:0001969] ... + |
PDP12AJ02988-4 | 9606 | Human | human | Homo sapiens | Age:23 Alternative names:F06 Body product:blood plasma [UBERON:0001969] ... + |
PDP12AJ03026-4 | 9606 | Human | human | Homo sapiens | Age:32 Alternative names:F07 Body product:blood plasma [UBERON:0001969] ... + |
PDP12AJ03070-4 | 9606 | Human | human | Homo sapiens | Age:22 Alternative names:A03 Body product:blood plasma [UBERON:0001969] ... + |