Data released on December 01, 2014
A total of 395 couples were subjected to IVF-PGD treatment, including 129 couples with NGS-based test and 266 couples with SNP array based test for the detection of embryonic chromosomal abnormalities. The NGS test was performed using low coverage whole genome sequencing with HiSeq 2000 platform. And the SNP array test was using Affymetrix Gene Chip Mapping Nsp I 262K. The average age of patients was 32.1 years (age range 20-44 years).
Due to the sensitive nature of this dataset it is being hosted in the secure restricted access database European Genome-Phenome Archive at the EBI. It has been assigned the accession number EGAD00001001037.
To gain access to this dataset you will need to apply for permission from the CITIC Xiangya Hospital and BGI PGD/PGS Data Access Committee (DAC).
There are two forms available to download from GigaDB FTP server (below), both should be completed and emailed to Dr Yueqiu Tan, who is the named representative of the CITIC Xiangya Hospital and BGI PGD/PGS DAC.
After sending the forms to the DAC you will be contacted either by the DAC to decline your application or from the EGA with login details if your application is approved. This process can take several days.
Tan, Y., Yin, X., Zhang, S., Jiang, H., Tan, K., Li, J., … Lin, G. (2014). Clinical outcome of preimplantation genetic diagnosis and screening using next generation sequencing. GigaScience, 3(1). doi:10.1186/2047-217x-3-30