The colorectal adenoma-carcinoma microbiome.

Dataset type: Metagenomic
Data released on May 06, 2015

Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gutmicrobe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.

Additional details

Read the peer-reviewed publication(s):


Accessions (data generated as part of this study):

ENA: ERP008729
BioProject: PRJEB7774





Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
SAMEA3136623408170Human gut metagenome human gut metagenome Alternative accession-SRA Sample:ERS608474
Alternative names:31766
Collection date:2013
...
+
SAMEA3136624408170Human gut metagenome human gut metagenome Alternative accession-SRA Sample:ERS608475
Alternative names:31537
Collection date:2013
...
+
SAMEA3136625408170Human gut metagenome human gut metagenome Alternative accession-SRA Sample:ERS608476
Alternative names:31600
Collection date:2013
...
+
SAMEA3136626408170Human gut metagenome human gut metagenome Alternative accession-SRA Sample:ERS608477
Alternative names:31428
Collection date:2013
...
+
SAMEA3136627408170Human gut metagenome human gut metagenome Alternative accession-SRA Sample:ERS608478
Alternative names:530167
Collection date:2013
...
+
SAMEA3136628408170Human gut metagenome human gut metagenome Alternative accession-SRA Sample:ERS608479
Alternative names:530315
Collection date:2013
...
+
SAMEA3136629408170Human gut metagenome human gut metagenome Alternative accession-SRA Sample:ERS608480
Alternative names:530050
Collection date:2013
...
+
SAMEA3136630408170Human gut metagenome human gut metagenome Alternative accession-SRA Sample:ERS608481
Alternative names:31160
Collection date:2013
...
+
SAMEA3136631408170Human gut metagenome human gut metagenome Alternative accession-SRA Sample:ERS608482
Alternative names:530177
Collection date:2013
...
+
SAMEA3136632408170Human gut metagenome human gut metagenome Alternative accession-SRA Sample:ERS608483
Alternative names:31700
Collection date:2013
...
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Displaying 1-10 of 156 Sample(s).




File NameSample IDData TypeFile FormatSizeRelease Date 
Coding sequenceFASTA850.39 MB2015-05-05
Protein sequenceFASTA591.79 MB2015-05-05
OtherTAR433.95 MB2015-05-05
OtherUNKNOWN372.25 KB2015-05-05
OtherUNKNOWN94.88 MB2015-05-05
ReadmeTEXT1.37 KB2015-05-05
Displaying 1-6 of 6 File(s).
Date Action
April 28, 2020 File size of readme.txt updated