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Data released on September 14, 2015

Supporting materials for "Metabolome of Human gut microbiome is predictive of host dysbiosis".

Dai, Y; Larsen, P, E (2015): Supporting materials for "Metabolome of Human gut microbiome is predictive of host dysbiosis". GigaScience Database. http://dx.doi.org/10.5524/100163 RIS BibTeX Text

Humans live in constant and vital symbiosis with a closely linked bacterial ecosystem, called the microbiome, which influences many aspects of human health. When this microbial ecosystem becomes disrupted, the health of the human host can suffer, a condition called dysbiosis. However, the community compositions of the human microbiomes also vary dramatically from individual to individual and over time, making it difficult to uncover the underlying mechanisms linking microbiome to human health. We propose that a microbiome’s interaction with its human host is not necessarily dependent upon the presence or absence of particular bacterial species, but instead is dependent on the community metabolome of microbiome, an emergent property of microbiome.
Using data from a previously published, longitudinal study of human gut microbiome populations, we extrapolated information about microbiome community enzyme profiles and metabolome models. Using machine learning techniques, we demonstrated that the microbiome’s aggregate predicted community enzyme function profiles and modeled metabolomes are more predictive of dysbiosis than either observed microbiome community composition or predicted enzyme function profiles.

Contact Submitter

Related manuscripts:

doi:10.1186/s13742-015-0084-3

Accessions (data not in GigaDB):

ENA: ERP006059

Keywords:

Dysbiosis Human gut microbiome Machine learning Metabolome modeling Metabolome modeling 

Network-Analysis, Software, Metagenomic

http://gigadb.org/images/data/cropped/100163.jpg

Funding:

  • Funding body - U.S. Department of Energy
  • Award ID - DE-AC02-06CH1135

Samples: Table Settings

Columns:

Common Name
Scienfic Name
Sample Attributes
Taxonomic ID
Genbank Name

Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
Donor A9606HumanhumanHomo sapiens Age:26
Geographic location (country and/or sea,region):US...
Body-mass index:19.4
...
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Donor B9606HumanhumanHomo sapiens Age:36
Geographic location (country and/or sea,region):US...
Body-mass index:21.5
...
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Displaying 1-2 of 2 Sample(s).

Files: (FTP site) Table Settings

Columns:

File Description
Sample ID
File Type
File Format
Size
Release Date
Download Link
File Attributes

File NameSample IDFile TypeFile FormatSizeRelease Date 
TextTEXT16.01 MB2015-08-31
TextTEXT9.98 MB2015-09-04
ScriptUNKNOWN1.97 KB2015-08-31
TextTEXT22.93 MB2015-08-31
TextTEXT309.21 KB2015-08-31
TextTEXT228.44 KB2015-08-31
OtherPDF547.65 KB2015-08-31
Otherzip14.03 MB2015-08-31
TextTEXT1.61 MB2015-09-04
TextTEXT14.25 MB2015-09-04
Displaying 1-10 of 12 File(s).

History:

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