Supporting data for "Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals"
Dataset type: Lipidomic
Data released on May 08, 2017
Zhong H; Fang C; Fan Y; Lu Y; Wen B; Ren H; Hou G; Yang F; Xie H; Jie Z; Peng Y; Ye Z; Wu J; Zi J; Zhao G; Chen J; Bao X; Hu Y; Gao Y; Zhang J; Yang H; Wang J; Madsen L; Kristiansen K; Ni C; Li J; Liu S (2017): Supporting data for "Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals" GigaScience Database. http://dx.doi.org/10.5524/100306
The relationship between dyslipidemia and type 2 diabetes (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized.
Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was applied to detect the global lipidome in fasting plasma of 293 Chinese individuals, including 114 T2D patients, 81 prediabetic subjects and 98 individuals with normal glucose tolerance (NGT). Both qualitative and quantitative analyses revealed a gradual change in plasma lipid features going from NGT individuals over prediabetic to T2D individuals with T2D patients exhibiting characteristics close to those in prediabetic individuals, whereas they differed significantly from individuals with NGT. We constructed and validated a random forest (RF) classifier with 28 lipidomic features that effectively discriminated T2D from NGT or prediabetes. The majority of the selected features showed significant correlations with diabetic clinical indices.
Hydroxybutyrylcarnitine was positively correlated with fasting plasma glucose (FPG), 2-hour postprandial glucose (2h-PG), glycated hemoglobin (HbA1c) and insulin resistance index (HOMA-IR), and lysophosphatidylcholines such as LysoPC (18:0), LysoPC (18:1) and LysoPC (18:2) were all negatively correlated with HOMA-IR.
Additional details
Read the peer-reviewed publication(s):
(PubMed: 28505362)
Accessions (data generated as part of this study):
MetaboLights:
MTBLS352
Sample ID | Taxonomic ID | Common Name | Genbank Name | Scientific Name | Sample Attributes |
---|---|---|---|---|---|
SD-B00001 | 9606 | Human | human | Homo sapiens | Description:fasting plasma sampled from 59 years o... Miscellaneous parameter:diagnosis:Normal Glucose T... Sex:F ... + |
SD-B00006 | 9606 | Human | human | Homo sapiens | Description:fasting plasma sampled from 67 years o... Miscellaneous parameter:diagnosis:Normal Glucose T... Sex:F ... + |
SD-B00007 | 9606 | Human | human | Homo sapiens | Description:fasting plasma sampled from 52 years o... Miscellaneous parameter:diagnosis:Normal Glucose T... Sex:F ... + |
SD-B00011 | 9606 | Human | human | Homo sapiens | Description:fasting plasma sampled from 63 years o... Miscellaneous parameter:diagnosis:type 2 diabetes ... Sex:F ... + |
SD-B00012 | 9606 | Human | human | Homo sapiens | Description:fasting plasma sampled from 49 years o... Miscellaneous parameter:diagnosis:prediabetes synd... Sex:F ... + |
SD-B00013 | 9606 | Human | human | Homo sapiens | Description:fasting plasma sampled from 54 years o... Miscellaneous parameter:diagnosis:Normal Glucose T... Sex:F ... + |
SD-B00014 | 9606 | Human | human | Homo sapiens | Description:fasting plasma sampled from 51 years o... Miscellaneous parameter:diagnosis:Normal Glucose T... Sex:F ... + |
SD-B00015 | 9606 | Human | human | Homo sapiens | Description:fasting plasma sampled from 56 years o... Miscellaneous parameter:diagnosis:Normal Glucose T... Sex:F ... + |
SD-B00017 | 9606 | Human | human | Homo sapiens | Description:fasting plasma sampled from 68 years o... Miscellaneous parameter:diagnosis:type 2 diabetes ... Sex:M ... + |
SD-B00020 | 9606 | Human | human | Homo sapiens | Description:fasting plasma sampled from 45 years o... Miscellaneous parameter:diagnosis:prediabetes synd... Sex:M ... + |