Supporting materials for "Kronos: a workflow assembler for genome analytics and informatics"

Dataset type: Software
Data released on June 14, 2017

Taghiyar MJ; Rosner J; Grewal D; Grande BM; Aniba R; Grewal J; Boutros PC; Morin RD; Bashashati A; Shah SP (2017): Supporting materials for "Kronos: a workflow assembler for genome analytics and informatics" GigaScience Database.


The field of next generation sequencing informatics has matured to a point where algorithmic advances in sequence alignment and individual feature detection methods have stabilized. Practical and robust implementation of complex analytical workflows (where such tools are structured into 'best practices' for automated analysis of NGS datasets) still requires significant programming investment and expertise.
We present Kronos, a software platform for facilitating the development and execution of modular, auditable and distributable bioinformatics workflows. Kronos obviates the need for explicit coding of workflows by compiling a text configuration file into executable Python applications. Making analysis modules would still require programming. The framework of each workflow includes a run manager to execute the encoded workflows locally (or on a cluster or cloud), parallelize tasks, and log all runtime events. Resulting workflows are highly modular and configurable by construction, facilitating flexible and extensible meta-applications which can be modified easily through configuration file editing. The workflows are fully encoded for ease of distribution and can be instantiated on external systems, a step towards reproducible research and comparative analyses. We introduce a framework for building Kronos components which function as shareable, modular nodes in Kronos workflows.
The Kronos platform provides a standard framework for developers to implement custom tools, reuse existing tools, and contribute to the community at large. Kronos is shipped with both Docker and Amazon AWS machine images. It is free, open source and available through PyPI (Python Package Index) and

Additional details

Read the peer-reviewed publication(s):

Taghiyar, M. J., Rosner, J., Grewal, D., Grande, B. M., Aniba, R., Grewal, J., … Shah, S. P. (2017). Kronos: a workflow assembler for genome analytics and informatics. GigaScience, 6(7). doi:10.1093/gigascience/gix042

Additional information: repositories

File NameSample IDData TypeFile FormatSizeRelease Date 
GitHub archivearchive336.12 KB2017-05-29
GitHub archivearchive6.16 KB2017-05-29
GitHub archivearchive903.76 KB2017-05-29
GitHub archivearchive3.69 KB2017-05-29
GitHub archivearchive3.62 KB2017-05-29
GitHub archivearchive20.47 KB2017-05-29
GitHub archivearchive7.66 MB2017-05-29
GitHub archivearchive3.79 KB2017-05-29
GitHub archivearchive2.95 KB2017-05-29
GitHub archivearchive6.43 KB2017-05-29
Displaying 1-10 of 42 File(s).
Funding body Awardee Award ID Comments
Natural Sciences and Engineering Research Council of Canada RGPGR 488167-2013 Main PI: Lincoln Stein - subproject PI: Sohrab P Shah
Genome Canada Sohrab P Shah 173CIC
Terry Fox Research Institute Sohrab P Shah 1021
Date Action
June 14, 2017 Dataset publish
October 2, 2017 Manuscript Link added : 10.1093/gigascience/gix042