16GT is a variant caller for Illumina whole-genome and whole-exome sequencing data. It uses a new 16-genotype probabilistic model to unify SNP and indel calling in a single variant calling algorithm. In benchmark comparisons with five other widely used variant callers on a modern 36-core server, 16GT demonstrated improved sensitivity in calling SNPs, and it provided comparable sensitivity and accuracy for calling indels as compared to the GATK HaplotypeCaller. 16GT is available at https://github.com/aquaskyline/16GT.

Keywords:

• Variant calling
• Bayesian model
• SNP calling
• Indel calling

Read the peer-reviewed publication(s):

(PubMed: 28637275)

Additional information:

https://github.com/aquaskyline/16GT