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Data released on March 16, 2018

Supporting data for "The gut microbiome in atherosclerotic cardiovascular disease"

Jie, Z; Xia, H; Zhong, S; Feng, Q; Li, S; Liang, S; Zhong, H; Liu, Z; Gao, Y; Zhao, H; Zhang, D; Su, Z; Fang, Z; Lan, Z; Li, J; Xiao, L; Li, J; Li, R; Li, X; Li, F; Ren, H; Huang, Y; Peng, Y; Li, G; 1,2, Bo Dong, B, W; Chen, J; Geng, Q; Zhang, Z; Yang, H; Wang, J; Wang, J; Zhang, X; Madsen, L; Brix, S; Ning, G; Xu, X; Liu, X; Hou, Y; Jia, H; He, K; Kristiansen, K (2018): Supporting data for "The gut microbiome in atherosclerotic cardiovascular disease" GigaScience Database. http://dx.doi.org/10.5524/100358 RIS BibTeX Text

The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. Although drug treatment represents a confounding factor, ACVD status, and not current drug use, is the major distinguishing feature in this cohort. We identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes), with liver cirrhosis, and rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases.

Contact Submitter

Read the peer-reviewed publication(s):

Jie, Z., Xia, H., Zhong, S.-L., Feng, Q., Li, S., Liang, S., … Kristiansen, K. (2017). The gut microbiome in atherosclerotic cardiovascular disease. Nature Communications, 8(1). doi:10.1038/s41467-017-00900-1

Accessions (data included in GigaDB):

SRA: ERP023788

Keywords:

Metagenomic

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Funding:

  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - JCYJ20160229172757249
  • Awardee - Huijue Jia
  • Funding body - Natural Science Foundation of China
  • Award ID - 81373486
  • Awardee - Shilong Zhao
  • Funding body - Natural Science Foundation of China
  • Award ID - 81673514
  • Awardee - Shilong Zhao
  • Funding body - National Key Research and Development Program of China
  • Award ID - SQ2017YFSF090209
  • Awardee - Kunlun he
  • Funding body - Science and Technology Development Projects of Guangdong Province
  • Award ID - 2016B090918114
  • Awardee - Shilong Zhong
  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - JSGG20160229172752028
  • Awardee - Junhua Li
  • Funding body - Fund for Science and Technology Development from Macao
  • Award ID - 077/2014/A2
  • Awardee - Jun Wang

Samples: Table Settings

Columns:

Common Name
Scienfic Name
Sample Attributes
Taxonomic ID
Genbank Name

Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
N001408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N002408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N003408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N005408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N006408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N009408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N011408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N013408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N017408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N020408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
Displaying 1-10 of 405 Sample(s).

Files: (FTP site) Table Settings

Columns:

File Description
Sample ID
Data Type
File Format
Size
Release Date
Download Link
File Attributes

File NameSample IDData TypeFile FormatSizeRelease Date 
otherUNKNOWN28.07 KB2018-02-17
otherUNKNOWN89.05 MB2018-02-17
MD5sumUNKNOWN0.18 KB2018-02-17
otherUNKNOWN4.48 MB2018-02-17
otherUNKNOWN15.9 MB2018-02-17
ReadmeTEXT2.15 KB2018-02-17
Displaying 1-6 of 6 File(s).

History:

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