Supporting data for "The gut microbiome in atherosclerotic cardiovascular disease"

Dataset type: Metagenomic
Data released on March 16, 2018

Jie Z; Xia H; Zhong S; Feng Q; Li S; Liang S; Zhong H; Liu Z; Gao Y; Zhao H; Zhang D; Su Z; Fang Z; Lan Z; Li J; Xiao L; Li J; Li R; Li X; Li F; Ren H; Huang Y; Peng Y; Li G; 1,2, Bo Dong BW; Chen J; Geng Q; Zhang Z; Yang H; Wang J; Wang J; Zhang X; Madsen L; Brix S; Ning G; Xu X; Liu X; Hou Y; Jia H; He K; Kristiansen K (2018): Supporting data for "The gut microbiome in atherosclerotic cardiovascular disease" GigaScience Database. http://dx.doi.org/10.5524/100358

DOI10.5524/100358

The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. Although drug treatment represents a confounding factor, ACVD status, and not current drug use, is the major distinguishing feature in this cohort. We identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes), with liver cirrhosis, and rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases.

Keywords:

Additional details

Read the peer-reviewed publication(s):

Jie, Z., Xia, H., Zhong, S.-L., Feng, Q., Li, S., Liang, S., … Kristiansen, K. (2017). The gut microbiome in atherosclerotic cardiovascular disease. Nature Communications, 8(1). doi:10.1038/s41467-017-00900-1

Accessions (data included in GigaDB):

SRA: ERP023788





Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
N001408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N002408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N003408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N005408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N006408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N009408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N011408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N013408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N017408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
N020408170Human gut metagenome human gut metagenome Description:Metagenomic DNA extracted from feacal ...
Host taxid:9606
Host common name:homo sapiens
...
+
Displaying 1-10 of 405 Sample(s).




File NameSample IDData TypeFile FormatSizeRelease Date 
otherUNKNOWN28.07 KB2018-02-17
otherUNKNOWN89.05 MB2018-02-17
MD5sumUNKNOWN0.18 KB2018-02-17
otherUNKNOWN4.48 MB2018-02-17
otherUNKNOWN15.9 MB2018-02-17
ReadmeTEXT2.15 KB2018-02-17
Displaying 1-6 of 6 File(s).
Funding body Awardee Award ID Comments
Shenzhen Municipal Government of China Huijue Jia JCYJ20160229172757249
Natural Science Foundation of China Shilong Zhao 81373486
Natural Science Foundation of China Shilong Zhao 81673514
National Key Research and Development Program of China Kunlun he SQ2017YFSF090209
Science and Technology Development Projects of Guangdong Province Shilong Zhong 2016B090918114
Shenzhen Municipal Government of China Junhua Li JSGG20160229172752028
Fund for Science and Technology Development from Macao Jun Wang 077/2014/A2
Date Action
March 16, 2018 Dataset publish