Supporting data for "Consistent decreased activity in the putamen in Parkinson's disease: A meta-analysis and an independent validation of resting-state fMRI"

Dataset type: Neuroscience, Imaging
Data released on May 18, 2018

Wang J; Zhang J; Zang Y; Wu T (2018): Supporting data for "Consistent decreased activity in the putamen in Parkinson's disease: A meta-analysis and an independent validation of resting-state fMRI" GigaScience Database. http://dx.doi.org/10.5524/100444

DOI10.5524/100444

Resting-state functional magnetic resonance imaging (RS-fMRI) has frequently been used to investigate local spontaneous brain activity in Parkinson’s disease (PD) in a whole-brain, voxel-wise manner. To quantitatively integrate these studies, we conducted a coordinate-based meta-analysis (CB meta-analysis), using the seed-based d mapping (SDM) method, on 15 studies that used amplitude of low frequency fluctuation (ALFF) and 11 studies that used regional homogeneity (ReHo). All these ALFF and ReHo studies have compared PD patients with healthy controls. We also performed a validation RS-fMRI study of ALFF and ReHo in a frequency-dependent manner for a novel dataset consisting of 49 PD and 49 healthy controls. Decreased ALFF was found in the left putamen in PD by meta-analysis. This finding was replicated in our independent validation dataset in the 0.027 - 0.073 Hz band, but not in the conventional frequency band of 0.01 - 0.08 Hz. Findings from the current study suggested that decreased ALFF in the putamen of PD is the most consistent finding. RS-fMRI is a promising technique for the precise localization of abnormal spontaneous activity in PD. However, more frequency-dependent studies using the same analytical methods are needed to replicate that results.

Additional details

Read the peer-reviewed publication(s):

Wang, J., Zhang, J.-R., Zang, Y.-F., & Wu, T. (2018). Consistent decreased activity in the putamen in Parkinson’s disease: a meta-analysis and an independent validation of resting-state fMRI. GigaScience, 7(6). doi:10.1093/gigascience/giy071

Additional information:

https://www.nitrc.org/projects/pdrsfmriwutao/





Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
HC0019606HumanhumanHomo sapiens Description:Resting-state functional magnetic reso...
Disease status:Healthy control
Age:64
...
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HC0029606HumanhumanHomo sapiens Description:Resting-state functional magnetic reso...
Disease status:Healthy control
Age:73
...
+
HC0039606HumanhumanHomo sapiens Description:Resting-state functional magnetic reso...
Disease status:Healthy control
Age:48
...
+
HC0049606HumanhumanHomo sapiens Description:Resting-state functional magnetic reso...
Disease status:Healthy control
Age:70
...
+
HC0059606HumanhumanHomo sapiens Description:Resting-state functional magnetic reso...
Disease status:Healthy control
Age:62
...
+
HC0069606HumanhumanHomo sapiens Description:Resting-state functional magnetic reso...
Disease status:Healthy control
Age:61
...
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HC0079606HumanhumanHomo sapiens Description:Resting-state functional magnetic reso...
Disease status:Healthy control
Age:71
...
+
HC0089606HumanhumanHomo sapiens Description:Resting-state functional magnetic reso...
Disease status:Healthy control
Age:75
...
+
HC0099606HumanhumanHomo sapiens Description:Resting-state functional magnetic reso...
Disease status:Healthy control
Age:77
...
+
HC0109606HumanhumanHomo sapiens Description:Resting-state functional magnetic reso...
Disease status:Healthy control
Age:64
...
+
Displaying 1-10 of 98 Sample(s).




File NameSample IDData TypeFile FormatSizeRelease Date 
Imagearchive57.79 MB2018-05-16
Imagearchive56.82 MB2018-05-16
Imagearchive76.6 MB2018-05-16
Imagearchive67.64 MB2018-05-16
Imagearchive155.32 MB2018-05-16
Imagearchive153.71 MB2018-05-16
Imagearchive173.85 MB2018-05-16
Imagearchive152.24 MB2018-05-16
Imagearchive153.99 MB2018-05-16
Imagearchive154.03 MB2018-05-16
Displaying 1-10 of 21 File(s).
Funding body Awardee Award ID Comments
Ministry of Science and Technology T Wu 2016YFC1306503 Structural and functional MRI research
National Natural Science Foundation of China Y Zang 81271652 The orientation system in Alzheimer's disease _ behavioral, functional and metabolic changes as predictors and markers of progression
Beijing Municipal Commission of Health and Family Planning T Wu No.PXM 2017_026283_000002 Research on the key technology of major geriatric disorders
National Natural Science Foundation of China Y Zang 31471084 fMRI study on frequency fluctuation of brain activity and sustained attention
National Natural Science Foundation of China Y Zang 81520108016 Amplitude of low frequency fluctuation of RS-fMRI: its physiological mechanisms and application to localization of TMS target
National Natural Science Foundation of China T Wu 81571228 Neural network changes in the pre-clinical stage of Parkinson's disease
Date Action
May 18, 2018 Dataset publish
July 9, 2018 Manuscript Link added : 10.1093/gigascience/giy071