Supporting data for "A databank for intracellular electrophysiological mapping of the adult somatosensory cortex"

Dataset type: Neuroscience, Electrophysiology
Data released on November 16, 2018

Lantyer Ad; Calcini N; Bijlsma A; Kole K; Emmelkamp M; Peeters M; Scheenen WJJ; Zeldenrust F; Celikel T (2018): Supporting data for "A databank for intracellular electrophysiological mapping of the adult somatosensory cortex" GigaScience Database. http://dx.doi.org/10.5524/100535

DOI10.5524/100535

Neurons in the supragranular layers of the somatosensory cortex integrate sensory (bottom-up) and cognitive/perceptual (top-down) information as they orchestrate communication across cortical columns. It has been inferred, based on intracellular recordings from juvenile animals, that supragranular neurons are electrically mature by the fourth postnatal week. However, the dynamics of the neuronal integration in the adulthood is largely unknown. Electrophysiological characterization of the active properties of these neurons throughout adulthood will help to address the biophysical and computational principles of the neuronal integration. Here we provide a database of whole-cell intracellular recordings from 294 neurons located in the supragranular layers (L2/3) of the primary somatosensory cortex in adult mice (9-45 weeks old) from both sexes (females, N=184; males, N=110). Data include 336 somatic current-clamp (CC) and 515 voltage-clamp (VC) experiments, recorded using a step-and-hold protocol (CC, N=236; VC, N=54), frozen noise injections (CC, N=100) and triangular voltage sweeps (VC, 10 (N=142), 50 (N=157) and 100 ms (N=162)), from regularly spiking (N=161) and fast-spiking neurons (N=78). The data could be used to systematically study the properties of somatic integration, and the principles of action potential generation across sexes and across electrically characterized neuronal classes in adulthood. Understanding the principles of the somatic transformation of postsynaptic potentials into action potentials will shed light onto the computational principles of intracellular information transfer in single neurons and information processing in neuronal networks, helping to recreate neuronal functions in artificial systems.

Additional details

Read the peer-reviewed publication(s):

Da Silva Lantyer, A., Calcini, N., Bijlsma, A., Kole, K., Emmelkamp, M., Peeters, M., … Celikel, T. (2018). A databank for intracellular electrophysiological mapping of the adult somatosensory cortex. GigaScience, 7(12). doi:10.1093/gigascience/giy147





Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
161104_NC_310090Mousehouse mouseMus musculus Description:Electrophysiology of the primary somat...
Age:192 days
Life stage:postnatal
...
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161214_AL_11310090Mousehouse mouseMus musculus Description:Electrophysiology of the primary somat...
Age:210 days
Life stage:postnatal
...
+
161214_NC_710090Mousehouse mouseMus musculus Description:Electrophysiology of the primary somat...
Age:210 days
Life stage:postnatal
...
+
170130_AL_13310090Mousehouse mouseMus musculus Description:Electrophysiology of the primary somat...
Age:226 days
Life stage:postnatal
...
+
170130_AL_13410090Mousehouse mouseMus musculus Description:Electrophysiology of the primary somat...
Age:226 days
Life stage:postnatal
...
+
170131_AB_21610090Mousehouse mouseMus musculus Description:Electrophysiology of the primary somat...
Age:227 days
Life stage:postnatal
...
+
170131_AB_21810090Mousehouse mouseMus musculus Description:Electrophysiology of the primary somat...
Age:227 days
Life stage:postnatal
...
+
170201_AB_22010090Mousehouse mouseMus musculus Description:Electrophysiology of the primary somat...
Age:228 days
Life stage:postnatal
...
+
170201_AB_22110090Mousehouse mouseMus musculus Description:Electrophysiology of the primary somat...
Age:228 days
Life stage:postnatal
...
+
170201_AB_22210090Mousehouse mouseMus musculus Description:Electrophysiology of the primary somat...
Age:228 days
Life stage:postnatal
...
+
Displaying 1-10 of 326 Sample(s).




File NameSample IDData TypeFile FormatSizeRelease Date 
161214_AL_113MatLabUNKNOWN64.99 MB2018-11-15
170130_AL_133MatLabUNKNOWN63.84 MB2018-11-15
170130_AL_134MatLabUNKNOWN64 MB2018-11-15
170131_AB_218MatLabUNKNOWN941.78 KB2018-11-15
170201_AB_220MatLabUNKNOWN988.46 KB2018-11-15
170201_AB_221MatLabUNKNOWN2.72 MB2018-11-15
170201_AB_222MatLabUNKNOWN988.46 KB2018-11-15
170202_NC_9MatLabUNKNOWN9.05 MB2018-11-15
170208_AB_232MatLabUNKNOWN916.69 KB2018-11-15
170209_AB_237MatLabUNKNOWN1.86 MB2018-11-15
Displaying 1-10 of 838 File(s).
Funding body Awardee Award ID Comments
European Commission T Celikel 660328 Horizon2020
European Regional Development Fund T Celikel 122035 MIND
Netherlands Organisation for Scientific Research T Celikel 824.14.022 NWO-ALW Open Competition
Netherlands Organisation for Scientific Research F Zeldenrust 863.150.25 NWO Veni Research Grant
Date Action
November 16, 2018 Dataset publish
December 3, 2018 Manuscript Link added : 10.1093/gigascience/giy147