Supporting data for "Addressing health disparities in Hispanic breast cancer: Accurate and inexpensive sequencing of BRCA1 and BRCA2".

Dataset type: Genomic
Data released on August 27, 2015

Arentz C; Barajas C; Bass S; Boland J; Dean M; Eggebeen R; Figueroa JA; Garland L; Hollis C; Im KM; Jones K; Lee HJ; Mitchell J; Nahleh Z; Nguyen DD; Perez M; Rath E; Roberson D; Robles V; Rodriguez-Herrera M; Sawitzke J; Yeager M; Zhang X (2015): Supporting data for "Addressing health disparities in Hispanic breast cancer: Accurate and inexpensive sequencing of BRCA1 and BRCA2". GigaScience Database. http://dx.doi.org/10.5524/100154

DOI10.5524/100154

Germline mutations in the BRCA1 and BRCA2 genes account for 20 to 25% of inherited breast cancer and about 10% of all breast cancer cases. Detection of BRCA mutation carriers can lead to therapeutic interventions such as mastectomy, oophorectomy, hormonal prevention therapy, improved screening, and targeted therapies such as PARP-inhibition. We estimate that African Americans and Hispanics are 4 to 5 times less likely to receive BRCA screening, despite having similar mutation frequencies as non-Jewish Caucasians and these populations have higher breast cancer mortality. To begin addressing this health disparity, we initiated a nationwide trial of BRCA testing of Latinas with breast cancer. Patients were recruited through community organizations, clinics, public events and through the mail and internet. Subjects completed the consent process and questionnaire, and provided a saliva sample by mail or in person. DNA from 120 subjects was used to sequence the entire BRCA1 and BRCA2 coding regions and splice sites, and validation of pathogenic mutations with a total material cost of $85/subject. Subjects ranged in age from 23-81 years (mean age of 51 years), 6% had bilateral disease, 57% were ER/PR+, 23% HER2+, and 17% had triple-negative disease.

Additional details

Read the peer-reviewed publication(s):

Dean, M., Boland, J., Yeager, M., Im, K. M., Garland, L., Rodriguez-Herrera, M., … Nahleh, Z. (2015). Addressing health disparities in Hispanic breast cancer: accurate and inexpensive sequencing of BRCA1 and BRCA2. GigaScience, 4(1). doi:10.1186/s13742-015-0088-z

Additional information:

https://clinicaltrials.gov/show/NCT01251900





Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
DL00997899606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997909606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997919606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997929606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997939606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997949606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997959606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997969606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997979606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
DL00997989606HumanhumanHomo sapiens Health or disease status of specific host at time of collection:Affected, breast cancer
Sex:female (EFO:0001265)
Displaying 1-10 of 134 Sample(s).




File NameSample IDData TypeFile FormatSizeRelease Date 
ReadmeTEXT1.72 KB2015-08-04
DL0099791OtherDOCX13.47 KB2015-08-04
OtherTEXT14.69 KB2015-08-04
DirectoryUNKNOWN46.65 KB2015-08-04
OtherEXCEL68.14 KB2015-08-04
OtherEXCEL69.82 KB2015-08-04
DirectoryUNKNOWN77.33 KB2015-08-04
OtherEXCEL130.5 KB2015-08-04
OtherEXCEL132.78 KB2015-08-04
OtherEXCEL190.3 KB2015-08-04
Displaying 1-10 of 17 File(s).
Date Action
August 27, 2015 Dataset publish
November 5, 2015 Manuscript Link added : 10.1186/s13742-015-0088-z