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Data released on May 08, 2017

Supporting data for "Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals"

Zhong, H; Fan, Y; Fang, C; Lu, Y; Wen, B; Hou, G; Ren, H; Yang, F; Xie, H; Jie, Z; Peng, Y; Ye, Z; Wu, J; Zi, J; Zhao, G; Chen, J; Bao, X; Hu, Y; Gao, Y; Zhang, J; Yang, H; Wang, J; Madsen, L; Kristiansen, K; Ni, C; Li, J; Liu, S (2017): Supporting data for "Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals" GigaScience Database. http://dx.doi.org/10.5524/100306 RIS BibTeX Text

The relationship between dyslipidemia and type 2 diabetes (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was applied to detect the global lipidome in fasting plasma of 293 Chinese individuals, including 114 T2D patients, 81 prediabetic subjects and 98 individuals with normal glucose tolerance (NGT). Both qualitative and quantitative analyses revealed a gradual change in plasma lipid features going from NGT individuals over prediabetic to T2D individuals with T2D patients exhibiting characteristics close to those in prediabetic individuals, whereas they differed significantly from individuals with NGT. We constructed and validated a random forest (RF) classifier with 28 lipidomic features that effectively discriminated T2D from NGT or prediabetes. The majority of the selected features showed significant correlations with diabetic clinical indices. Hydroxybutyrylcarnitine was positively correlated with fasting plasma glucose (FPG), 2-hour postprandial glucose (2h-PG), glycated hemoglobin (HbA1c) and insulin resistance index (HOMA-IR), and lysophosphatidylcholines such as LysoPC (18:0), LysoPC (18:1) and LysoPC (18:2) were all negatively correlated with HOMA-IR.

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Accessions (data included in GigaDB):

MetaboLights: MTBLS352

Keywords:

Lipidomics Type 2 diabetes Prediabetes Plasma 

Lipidomic

http://gigadb.org/images/data/cropped/100306.jpg

Funding:

  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - JSGG20160229172752028
  • Awardee - Dr Junhua Li
  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - JSGG20140702161403250
  • Awardee - Dr Junhua Li
  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - CXB201108250098A
  • Awardee - Dr Junhua Li
  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - DRC-SZ [2015]162
  • Awardee - Dr Junhua Li
  • Funding body - Suzhou Biobank
  • Award ID - SS201111
  • Awardee - Mr Yihe Hu

Samples: Table Settings

Columns:

Common Name
Scienfic Name
Sample Attributes
Taxonomic ID
Genbank Name

Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
SD-B000259606HumanhumanHomo sapiens Description:fasting plasma sampled from 57 years o...
Miscellaneous parameter:diagnosis:Normal Glucose T...
Sex:M
...
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SD-B000299606HumanhumanHomo sapiens Description:fasting plasma sampled from 41 years o...
Miscellaneous parameter:diagnosis:Normal Glucose T...
Sex:F
...
+
SD-B000309606HumanhumanHomo sapiens Description:fasting plasma sampled from 63 years o...
Miscellaneous parameter:diagnosis:Normal Glucose T...
Sex:F
...
+
SD-B000329606HumanhumanHomo sapiens Description:fasting plasma sampled from 49 years o...
Miscellaneous parameter:diagnosis:Normal Glucose T...
Sex:F
...
+
SD-B000339606HumanhumanHomo sapiens Description:fasting plasma sampled from 63 years o...
Miscellaneous parameter:diagnosis:Normal Glucose T...
Sex:F
...
+
SD-B000349606HumanhumanHomo sapiens Description:fasting plasma sampled from 62 years o...
Miscellaneous parameter:diagnosis:prediabetes synd...
Sex:M
...
+
SD-B000369606HumanhumanHomo sapiens Description:fasting plasma sampled from 60 years o...
Miscellaneous parameter:diagnosis:Normal Glucose T...
Sex:F
...
+
SD-B000389606HumanhumanHomo sapiens Description:fasting plasma sampled from 55 years o...
Miscellaneous parameter:diagnosis:prediabetes synd...
Sex:F
...
+
SD-B000409606HumanhumanHomo sapiens Description:fasting plasma sampled from 50 years o...
Miscellaneous parameter:diagnosis:Normal Glucose T...
Sex:F
...
+
SD-B000019606HumanhumanHomo sapiens Description:fasting plasma sampled from 59 years o...
Miscellaneous parameter:diagnosis:Normal Glucose T...
Sex:F
...
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Displaying 11-20 of 293 Sample(s).

Files: (FTP site) Table Settings

Columns:

File Description
Sample ID
File Type
File Format
Size
Release Date
Download Link
File Attributes

File NameSample IDFile TypeFile FormatSizeRelease Date 
ScriptTEXT2.97 KB2017-04-26
ScriptTEXT15.35 KB2017-04-26
otherTEXT0.18 KB2017-04-26
otherTEXT0.5 KB2017-04-26
otherTEXT1.15 KB2017-04-26
tabular dataCSV596.48 KB2017-04-26
tabular dataCSV591.41 KB2017-04-26
TextTEXT8.13 KB2017-04-26
TextTEXT8.15 KB2017-04-26
ScriptTEXT0.95 KB2017-04-26
Displaying 1-10 of 39 File(s).

History:

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