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Data released on July 11, 2017

Supporting data for "Connections between human gut microbiome and gestational diabetes mellitus"

Kuang, Y; Li, J; Li, S; Lu, J; Yuan, M; Chen, N; He, J; Xiao, W; Shen, S; Qiu, L; Wu, Y; Hu, C; Wu, Y; Li, W; Chen, Q; Deng, H; Papasian, C, J; Xia, H; Qiu, X (2017): Supporting data for "Connections between human gut microbiome and gestational diabetes mellitus" GigaScience Database. http://dx.doi.org/10.5524/100326 RIS BibTeX Text

The human gut microbiome can modulate metabolic health and affect insulin resistance, and may play an important role in the etiology of gestational diabetes mellitus (GDM). Here, we compared the gut microbial composition of 43 GDM patients and 81 healthy pregnant women via whole-metagenome shotgun sequencing of their fecal samples collected at 21-29 weeks, to explore associations between GDM and the composition of microbial taxonomic units and functional genes. Metagenome-wide association study (MGWAS) identified 154,837 genes, which clustered into 129 metagenome linkage groups (MLGs) for species description, with significant relative abundance differences between the two cohorts. Parabacteroides distasonis, Klebsiella variicola, etc., were enriched in GDM patients, whereas Methanobrevibacter smithii, Alistipes spp., Bifidobacterium spp. and Eubacterium spp. were enriched in controls. The ratios of the gross abundances of GDM-enriched MLGs to control-enriched MLGs were positively correlated with blood glucose levels. Random Forest model shows fecal MLGs have excellent discriminatory power to predict GDM status.

Contact Submitter

Accessions (data included in GigaDB):

SRA: ERP020710

Keywords:

Gut microbiome gestational diabetes mellitus metagenome-wide association. 

Metagenomic

http://gigadb.org/images/data/cropped/100326.jpg

Funding:

  • Funding body - National Natural Science Foundation of China
  • Award ID - 81673181
  • Awardee - X Qiu
  • Funding body - Guangzhou Science and Technology Bureau
  • Location - China
  • Award ID - 201508030037
  • Awardee - X Qiu
  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - JSGG20160229172752028
  • Awardee - J-H Li
  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - CXB201108250098A
  • Awardee - J-H Li
  • Funding body - Shenzhen Municipal Government of China
  • Location - China
  • Award ID - JSGG20140702161403250
  • Awardee - J-H Li

Samples: Table Settings

Columns:

Common Name
Scienfic Name
Sample Attributes
Taxonomic ID
Genbank Name

Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
C001408170Human gut metagenome human gut metagenome Age:30
Weight:72
Height:160
...
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C002408170Human gut metagenome human gut metagenome Age:29
Weight:61
Height:160
...
+
C006408170Human gut metagenome human gut metagenome Age:29
Weight:55
Height:165
...
+
C008408170Human gut metagenome human gut metagenome Age:26
Weight:58
Height:168
...
+
C011408170Human gut metagenome human gut metagenome Age:32
Weight:not recorded
Height:not recorded
...
+
C012408170Human gut metagenome human gut metagenome Age:20
Weight:47.5
Height:160
...
+
C013408170Human gut metagenome human gut metagenome Age:25
Weight:50
Height:160
...
+
C014408170Human gut metagenome human gut metagenome Age:36
Weight:56
Height:172
...
+
C015408170Human gut metagenome human gut metagenome Age:39
Weight:48
Height:160
...
+
C016408170Human gut metagenome human gut metagenome Age:28
Weight:51
Height:160
...
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Displaying 1-10 of 124 Sample(s).

Files: (FTP site) Table Settings

Columns:

File Description
Sample ID
File Type
File Format
Size
Release Date
Download Link
File Attributes

File NameSample IDFile TypeFile FormatSizeRelease Date 
Tabular DataCSV16.14 KB2017-07-06
Tabular DataCSV2.41 KB2017-07-06
C001Coding sequenceUNKNOWN56.11 MB2017-07-06
C001Sequence assemblyUNKNOWN62.92 MB2017-07-06
C002Coding sequenceUNKNOWN55.09 MB2017-07-06
C002Sequence assemblyUNKNOWN61.75 MB2017-07-06
C006Coding sequenceUNKNOWN69.23 MB2017-07-06
C006Sequence assemblyUNKNOWN77.43 MB2017-07-06
C008Coding sequenceUNKNOWN66.59 MB2017-07-06
C008Sequence assemblyUNKNOWN74.56 MB2017-07-06
Displaying 1-10 of 269 File(s).

History:

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