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Data released on August 25, 2017

Supporting data for "Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis"

Zeng, C; Wen, B; Hou, G; Lei, L; Mei, Z; Jia, X; Chen, X; Zhu, W; Li, J; Kuang, Y; Zeng, W; Su, J; Liu, S; Peng, C; Chen, X (2017): Supporting data for "Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis" GigaScience Database. http://dx.doi.org/10.5524/100341 RIS BibTeX Text

Psoriasis is a common and chronic inflammatory skin disease complicated by genetic-environmental interactions. Although genomic, transcriptomic and proteomic analyses have been performed to investigate the pathogenesis of psoriasis, the role of metabolites in psoriasis, particularly of lipids, remains unclear. Lipids not only comprise the bulk of the cellular membrane bilayers but also regulate a variety of biological processes, such as cell proliferation, apoptosis, immunity, angiogenesis and inflammation.
In this study, an untargeted lipidomics approach was used to study the lipid profiles in psoriasis and identify lipid metabolite signatures for psoriasis through ultra-performance liquid chromatography-quadrupole tandem mass spectrometry. Plasma samples from 90 participants (45 healthy and 45 psoriasis patients) were collected and detected. Statistical analysis was applied to find different features between the two subjects. In addition, ELISA was performed to examine differential expression lipids in psoriatic patient plasma. We finally identified several differential expression lipids including LPAs, LysoPCs, PIs, PCs and PAs, among these metabolites, LPAs, LysoPCs and PAs were significantly increased, while PCs and PIs were down-regulated in psoriasis group.

Contact Submitter

Additional information:

https://github.com/ZengVera/psoriasis

Accessions (data included in GigaDB):

MTBLS: MTBLS408

Keywords:

Psoriasis Lipidomics Glycerophospholipid Metabolomics MS/MS 

Lipidomic

http://gigadb.org/images/data/cropped/100341.jpg

Funding:

  • Funding body - National Natural Science Foundation of China
  • Award ID - 81430075
  • Comment - key project
  • Awardee - X Chen
  • Funding body - National Natural Science Foundation of China
  • Award ID - 81572679
  • Awardee - C Peng
  • Funding body - Natural Science Foundation of Hunan province
  • Location - China
  • Award ID - 2015JJ2161
  • Awardee - C Peng

Samples: Table Settings

Columns:

Common Name
Scienfic Name
Sample Attributes
Taxonomic ID
Genbank Name

Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
MS15006013_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS15006014_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS150060169606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
+
MS150060179606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
+
MS150060189606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
+
MS150060209606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
+
MS150060219606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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MS150060239606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
+
MS150060249606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
+
MS15006001_POS9606HumanhumanHomo sapiens Description:plasma sample
Analyte type:lipids
Experiment type:LC-MS/MS
...
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Displaying 11-20 of 90 Sample(s).

Files: (FTP site) Table Settings

Columns:

File Description
Sample ID
File Type
File Format
Size
Release Date
Download Link
File Attributes

File NameSample IDFile TypeFile FormatSizeRelease Date 
Tabular dataCSV8.25 MB2017-08-23
Tabular dataCSV14.62 MB2017-08-23
GitHub archivearchive76.98 MB2017-08-21
ReadmeTEXT1.93 KB2017-08-21
Displaying 1-4 of 4 File(s).

History:

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