Supporting data for "Advanced lesion symptom mapping analyses and implementation as BCBtoolkit"

Dataset type: Software, Imaging
Data released on February 08, 2018

Foulon C; Cerliani L; Kinkingnéhun S; Levy R; Rosso C; Urbanski M; Volle E; de Schotten MT (2018): Supporting data for "Advanced lesion symptom mapping analyses and implementation as BCBtoolkit" GigaScience Database. http://dx.doi.org/10.5524/100399

DOI10.5524/100399

Patients with brain lesions provide a unique opportunity to understand the functioning of the human mind. However, even when focal, brain lesions have local and remote effects that impact functionally and structurally connected circuits. Similarly, function emerges from the interaction between brain areas rather than their sole activity. For instance, category fluency requires the association between executive, semantic and language functions. Here we provide, for the first time, a set of complementary solutions to measure the impact of a given lesion upon the neuronal circuits. Our methods, which were applied to 37 patients with a focal frontal brain lesion, revealed a large set of directly and indirectly disconnected brain regions that had significantly impacted category fluency performance. The directly disconnected regions corresponded to areas that are classically considered as functionally engaged in verbal fluency and categorization tasks. These regions were also organized into larger directly and indirectly disconnected functional networks, including the left ventral fronto-parietal network, whose cortical thickness correlated with performance on category fluency. The combination of structural and functional connectivity together with cortical thickness estimates reveal the remote effects of brain lesions, provide for the identification of the affected networks and strengthen our understanding of their relationship with cognitive and behavioural measures. The methods presented are available and freely accessible in the BCBtoolkit as supplementary software (http://toolkit.bcblab.com).

Keywords:

Additional details

Read the peer-reviewed publication(s):

Foulon, C., Cerliani, L., Kinkingnéhun, S., Levy, R., Rosso, C., Urbanski, M., … Thiebaut de Schotten, M. (2018). Advanced lesion symptom mapping analyses and implementation as BCBtoolkit. GigaScience, 7(3). doi:10.1093/gigascience/giy004

Additional information:

http://toolkit.bcblab.com





Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
P019606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:cerebrovascular disease
Age:56
...
+
P029606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:hematoma
Age:55
...
+
P039606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:cerebrovascular disease
Age:46
...
+
P049606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:surgery
Age:50
...
+
P059606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:cerebrovascular disease
Age:64
...
+
P069606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:epilepsy
Age:32
...
+
P079606HumanhumanHomo sapiens Description:Weighted registration to MNI152 refere...
Disease status:cerebrovascular disease
Age:51
...
+
P089606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:surgery
Age:70
...
+
P099606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:hematoma
Age:47
...
+
P109606HumanhumanHomo sapiens Description:Weighted registration to MNI152 refere...
Disease status:hematoma
Age:62
...
+
Displaying 1-10 of 37 Sample(s).




File NameSample IDData TypeFile FormatSizeRelease Date 
ArticlePDF117.88 KB2018-01-19
P02ImageUNKNOWN35.9 KB2018-01-05
P07ImageUNKNOWN47.41 KB2018-01-05
P04ImageUNKNOWN48.06 KB2018-01-05
P05ImageUNKNOWN38.5 KB2018-01-05
P06ImageUNKNOWN31.68 KB2018-01-05
P03ImageUNKNOWN33.45 KB2018-01-05
P08ImageUNKNOWN37.61 KB2018-01-05
P01ImageUNKNOWN27.75 KB2018-01-05
P09ImageUNKNOWN31.13 KB2018-01-05
Displaying 1-10 of 42 File(s).
Funding body Awardee Award ID Comments
Agence Nationale de la Recherche E Volle ANR-09-RPDOC-004-01
Agence Nationale de la Recherche M Thiebaut de Schotten ANR-13- JSV4-0001-01
Agence Nationale de la Recherche ANR-10-IAIHU-06 Investissements d’avenir
Fondation pour la Recherche Médicale R Levy
Date Action
February 8, 2018 Dataset publish
February 9, 2018 Manuscript Link added : 10.1093/gigascience/giy004