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Data released on February 08, 2018

Supporting data for "Advanced lesion symptom mapping analyses and implementation as BCBtoolkit"

Foulon, C; Cerliani, L; Kinkingnéhun, S; Levy, R; Rosso, C; Urbanski, M; Volle, E; de Schotten, M, T (2018): Supporting data for "Advanced lesion symptom mapping analyses and implementation as BCBtoolkit" GigaScience Database. http://dx.doi.org/10.5524/100399 RIS BibTeX Text

Patients with brain lesions provide a unique opportunity to understand the functioning of the human mind. However, even when focal, brain lesions have local and remote effects that impact functionally and structurally connected circuits. Similarly, function emerges from the interaction between brain areas rather than their sole activity. For instance, category fluency requires the association between executive, semantic and language functions. Here we provide, for the first time, a set of complementary solutions to measure the impact of a given lesion upon the neuronal circuits. Our methods, which were applied to 37 patients with a focal frontal brain lesion, revealed a large set of directly and indirectly disconnected brain regions that had significantly impacted category fluency performance. The directly disconnected regions corresponded to areas that are classically considered as functionally engaged in verbal fluency and categorization tasks. These regions were also organized into larger directly and indirectly disconnected functional networks, including the left ventral fronto-parietal network, whose cortical thickness correlated with performance on category fluency. The combination of structural and functional connectivity together with cortical thickness estimates reveal the remote effects of brain lesions, provide for the identification of the affected networks and strengthen our understanding of their relationship with cognitive and behavioural measures. The methods presented are available and freely accessible in the BCBtoolkit as supplementary software (http://toolkit.bcblab.com).

Contact Submitter

Read the peer-reviewed publication(s):

Foulon, C., Cerliani, L., Kinkingnéhun, S., Levy, R., Rosso, C., Urbanski, M., … Thiebaut de Schotten, M. (2018). Advanced lesion symptom mapping analyses and implementation as BCBtoolkit. GigaScience, 7(3). doi:10.1093/gigascience/giy004

Additional information:

http://toolkit.bcblab.com

Keywords:

Software, Imaging

http://gigadb.org/images/data/cropped/100399.jpg

Funding:

  • Funding body - Agence Nationale de la Recherche
  • Award ID - ANR-09-RPDOC-004-01
  • Awardee - E Volle
  • Funding body - Agence Nationale de la Recherche
  • Award ID - ANR-13- JSV4-0001-01
  • Awardee - M Thiebaut de Schotten
  • Funding body - Agence Nationale de la Recherche
  • Award ID - ANR-10-IAIHU-06
  • Comment - Investissements d’avenir
  • Funding body - Fondation pour la Recherche Médicale
  • Awardee - R Levy

Samples: Table Settings

Columns:

Common Name
Scienfic Name
Sample Attributes
Taxonomic ID
Genbank Name

Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
P119606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:surgery
Age:41
...
+
P129606HumanhumanHomo sapiens Description:Weighted registration to MNI152 refere...
Disease status:hematoma
Age:46
...
+
P139606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:cerebrovascular disease
Age:67
...
+
P149606HumanhumanHomo sapiens Description:Weighted registration to MNI152 refere...
Disease status:hematoma
Age:49
...
+
P159606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:surgery
Age:36
...
+
P169606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:hematoma
Age:40
...
+
P179606HumanhumanHomo sapiens Description:Weighted registration to MNI152 refere...
Disease status:hematoma
Age:40
...
+
P189606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:surgery
Age:23
...
+
P199606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:cerebrovascular disease
Age:54
...
+
P209606HumanhumanHomo sapiens Description:Enantiomorphic filling of damaged area...
Disease status:hematoma
Age:71
...
+
Displaying 11-20 of 37 Sample(s).

Files: (FTP site) Table Settings

Columns:

File Description
Sample ID
Data Type
File Format
Size
Release Date
Download Link
File Attributes

File NameSample IDData TypeFile FormatSizeRelease Date 
Mixed archiveTAR7.13 GB2018-01-05
Mixed archivearchive7.13 GB2018-01-05
ArticlePDF117.88 KB2018-01-19
Imagezip56.83 MB 
P10ImageUNKNOWN36.23 KB2018-01-05
P11ImageUNKNOWN37.12 KB2018-01-05
P12ImageUNKNOWN30.86 KB2018-01-05
P13ImageUNKNOWN28.68 KB2018-01-05
P14ImageUNKNOWN34.14 KB2018-01-05
P15ImageUNKNOWN34.85 KB2018-01-05
Displaying 1-10 of 42 File(s).

History:

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