Supporting data for ‘Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization’

Dataset type: Genomic
Data released on February 22, 2018

Pan Z; Li S; Liu Q; Wang Z; Zhou Z; Di R; Miao B; Hu W; Wang X; Hu X; Xu Z; Wei D; He X; Yuan L; Guo X; Liang B; Wang R; Li X; Cao X; Dong X; Xia Q; Shi H; Hao G; Yang J; Luosang C; Zhao Y; Jin M; Zhang Y; Lv S; Li F; Ding G; Chu M; Li Y (2018): Supporting data for ‘Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization’ GigaScience Database. http://dx.doi.org/10.5524/100408

DOI10.5524/100408

Animal domestication has been extensively studied but the process of feralization remains poorly understood. Here, we performed whole-genome sequencing of 99 sheep and identified a primary genetic divergence between two heterogeneous populations in the Tibetan Plateau, including one semi-feral lineage. Selective sweep and candidate gene analysis revealed the local adaptations of these sheep associated with sensory perception, muscle strength, eating habit, mating process and aggressive behavior. In particular, a horn-related gene RXFP2 showed signs of rapid evolution specifically in the semi-feral breeds. A unique haplotype and repressed horn-related-tissue expressions of RXFP2 were correlated with higher horn length, as well as spiral and horizontally extended horn shape. Semi-feralization has an extensive impact on diverse phenotypic traits of sheep. By acquiring features like those of their wild ancestors, semi-feral sheep were able to re-gain fitness in frequent contact with wild surroundings and rare human interventions. The present study provides a new insight into the evolution of domestic animals when human interventions are no longer dominant.

Additional details

Read the peer-reviewed publication(s):

Pan, Z., Li, S., Liu, Q., Wang, Z., Zhou, Z., Di, R., … Li, Y. (2018). Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization. GigaScience, 7(4). doi:10.1093/gigascience/giy019

Accessions (data included in GigaDB):

BioProject: PRJEB23437

Accessions (data not in GigaDB):

GENBANK: GCA_000298735.1





Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
PT19940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Prairie Tibe...
Sex:male
...
+
PT109940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Prairie Tibe...
Sex:female
...
+
PT29940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Prairie Tibe...
Sex:male
...
+
PT39940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Prairie Tibe...
Sex:male
...
+
PT49940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Prairie Tibe...
Sex:male
...
+
PT59940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Prairie Tibe...
Sex:male
...
+
PT69940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Prairie Tibe...
Sex:female
...
+
PT79940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Prairie Tibe...
Sex:female
...
+
PT89940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Prairie Tibe...
Sex:female
...
+
PT99940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Prairie Tibe...
Sex:female
...
+
Displaying 51-60 of 99 Sample(s).




File NameSample IDData TypeFile FormatSizeRelease Date 
Sequence variantsVCF14.76 GB2018-02-21
imageJPG41.63 KB2018-02-21
imageJPG4.09 MB2018-02-21
imageJPG3.29 MB2018-02-21
imageJPG318.05 KB2018-02-21
imageJPG1.13 MB2018-02-21
imageJPG1.13 MB2018-02-21
scriptPerl2.15 KB2018-02-21
scriptPerl2.68 KB2018-02-21
imageJPG153.14 KB2018-02-21
Displaying 1-10 of 46 File(s).
Funding body Awardee Award ID Comments
Ministry of Science and Technology of the People's Republic of China Y Li 2013BAI101B09 National Key Technology Support Program
Ministry of Science and Technology of the People's Republic of China Y Li 2012YQ03026108 National Key Scientific Instrument and Equipment Development Project
Ministry of Science and Technology of the People's Republic of China Y Li 2011CB910204 National Basic Research Program of China
Ministry of Science and Technology of the People's Republic of China Y Li 2011CB510102 National Basic Research Program of China
Youth Innovation Promotion Association of the Chinese Academy of Sciences Z Wang 2017325 Youth Innovation Promotion Association Support
Inner Mongolia Autonomous Region M Chu IMZX2014-001 Major Science and Technology Program of Inner Mongolia Autonomous Region of China
Ministry of Agriculture of the People's Republic of China M Chu ASTIP-IAS13 Agricultural Science and Technology Innovation Program of China
Ministry of Agriculture of the People's Republic of China M Chu CARS-39 Earmarked Fund for China Agriculture Research System
National Natural Science Foundation of China M Chu 31472078 National Natural Science Foundation of China
National Natural Science Foundation of China Q Liu 31402041 National Natural Science Foundation of China
Ministry of Science and Technology of the People's Republic of China Q Liu 2016ZX08009-003-006 Genetically Modified Organisms Breeding Major Program of China
Ministry of Science and Technology of the People's Republic of China M Chu 2016ZX08010-005-003 Genetically Modified Organisms Breeding Major Program of China
Date Action
February 22, 2018 Dataset publish
July 3, 2018 Manuscript Link added : 10.1093/gigascience/giy019