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Data released on February 22, 2018

Supporting data for ‘Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization’

Pan, Z; Li, S; Liu, Q; Wang, Z; Zhou, Z; Di, R; Miao, B; Hu, W; Wang, X; Hu, X; Xu, Z; Wei, D; He, X; Yuan, L; Guo, X; Liang, B; Wang, R; Li, X; Cao, X; Dong, X; Xia, Q; Shi, H; Hao, G; Yang, J; Luosang, C; Zhao, Y; Jin, M; Zhang, Y; Lv, S; Li, F; Ding, G; Chu, M; Li, Y (2018): Supporting data for ‘Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization’ GigaScience Database. http://dx.doi.org/10.5524/100408 RIS BibTeX Text

Animal domestication has been extensively studied but the process of feralization remains poorly understood. Here, we performed whole-genome sequencing of 99 sheep and identified a primary genetic divergence between two heterogeneous populations in the Tibetan Plateau, including one semi-feral lineage. Selective sweep and candidate gene analysis revealed the local adaptations of these sheep associated with sensory perception, muscle strength, eating habit, mating process and aggressive behavior. In particular, a horn-related gene RXFP2 showed signs of rapid evolution specifically in the semi-feral breeds. A unique haplotype and repressed horn-related-tissue expressions of RXFP2 were correlated with higher horn length, as well as spiral and horizontally extended horn shape. Semi-feralization has an extensive impact on diverse phenotypic traits of sheep. By acquiring features like those of their wild ancestors, semi-feral sheep were able to re-gain fitness in frequent contact with wild surroundings and rare human interventions. The present study provides a new insight into the evolution of domestic animals when human interventions are no longer dominant.

Contact Submitter

Accessions (data included in GigaDB):

BioProject: PRJEB23437

Accessions (data not in GigaDB):

GENBANK: GCA_000298735.1

Keywords:

domestic animal sheep adaptive evolution artificial selection semi-feralization horn 

Genomic

http://gigadb.org/images/data/cropped/100408.jpg

Funding:

  • Funding body - Ministry of Science and Technology of the People's Republic of China
  • Award ID - 2013BAI101B09
  • Comment - National Key Technology Support Program
  • Awardee - Y Li
  • Funding body - Ministry of Science and Technology of the People's Republic of China
  • Award ID - 2012YQ03026108
  • Comment - National Key Scientific Instrument and Equipment Development Project
  • Awardee - Y Li
  • Funding body - Ministry of Science and Technology of the People's Republic of China
  • Award ID - 2011CB910204
  • Comment - National Basic Research Program of China
  • Awardee - Y Li
  • Funding body - Ministry of Science and Technology of the People's Republic of China
  • Award ID - 2011CB510102
  • Comment - National Basic Research Program of China
  • Awardee - Y Li
  • Funding body - Youth Innovation Promotion Association of the Chinese Academy of Sciences
  • Award ID - 2017325
  • Comment - Youth Innovation Promotion Association Support
  • Awardee - Z Wang
  • Funding body - Inner Mongolia Autonomous Region
  • Award ID - IMZX2014-001
  • Comment - Major Science and Technology Program of Inner Mongolia Autonomous Region of China
  • Awardee - M Chu
  • Funding body - Ministry of Agriculture of the People's Republic of China
  • Location - China
  • Award ID - ASTIP-IAS13
  • Comment - Agricultural Science and Technology Innovation Program of China
  • Awardee - M Chu
  • Funding body - Ministry of Agriculture of the People's Republic of China
  • Location - China
  • Award ID - CARS-39
  • Comment - Earmarked Fund for China Agriculture Research System
  • Awardee - M Chu
  • Funding body - National Natural Science Foundation of China
  • Award ID - 31472078
  • Comment - National Natural Science Foundation of China
  • Awardee - M Chu
  • Funding body - National Natural Science Foundation of China
  • Award ID - 31402041
  • Comment - National Natural Science Foundation of China
  • Awardee - Q Liu
  • Funding body - Ministry of Science and Technology of the People's Republic of China
  • Award ID - 2016ZX08009-003-006
  • Comment - Genetically Modified Organisms Breeding Major Program of China
  • Awardee - Q Liu
  • Funding body - Ministry of Science and Technology of the People's Republic of China
  • Award ID - 2016ZX08010-005-003
  • Comment - Genetically Modified Organisms Breeding Major Program of China
  • Awardee - M Chu

Samples: Table Settings

Columns:

Common Name
Scienfic Name
Sample Attributes
Taxonomic ID
Genbank Name

Sample IDTaxonomic IDCommon NameGenbank NameScientific NameSample Attributes
T109940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Tan sheep (T...
Sex:female
...
+
T29940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Tan sheep (T...
Sex:male
...
+
T39940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Tan sheep (T...
Sex:male
...
+
T49940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Tan sheep (T...
Sex:male
...
+
T59940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Tan sheep (T...
Sex:male
...
+
T69940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Tan sheep (T...
Sex:female
...
+
T79940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Tan sheep (T...
Sex:female
...
+
T89940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Tan sheep (T...
Sex:female
...
+
T99940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Tan sheep (T...
Sex:female
...
+
VT19940SheepsheepOvis aries Alternative names:sheep
Description:Genomic DNA isolated from Valley Tibet...
Sex:male
...
+
Displaying 71-80 of 99 Sample(s).

Files: (FTP site) Table Settings

Columns:

File Description
Sample ID
Data Type
File Format
Size
Release Date
Download Link
File Attributes

File NameSample IDData TypeFile FormatSizeRelease Date 
Sequence variantsVCF14.76 GB2018-02-21
imageJPG41.63 KB2018-02-21
imageJPG4.09 MB2018-02-21
imageJPG3.29 MB2018-02-21
imageJPG318.05 KB2018-02-21
imageJPG1.13 MB2018-02-21
imageJPG1.13 MB2018-02-21
scriptPerl2.15 KB2018-02-21
scriptPerl2.68 KB2018-02-21
imageJPG153.14 KB2018-02-21
Displaying 1-10 of 46 File(s).

History:

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